Displaying similar documents to “Mathematically Modelling The Dissolution Of Solid Dispersions”

A model of cardiac tissue as an excitable medium with two interacting pacemakers having refractory time

Alexander Loskutov, Sergei Rybalko, Ekaterina Zhuchkova (2003)

Banach Center Publications

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A quite general model of the nonlinear interaction of two impulse systems describing some types of cardiac arrhythmias is developed. Taking into account a refractory time the phase locking phenomena are investigated. Effects of the tongue splitting and their interweaving in the parametric space are found. The results obtained allow us to predict the behavior of excitable systems with two pacemakers depending on the type and intensity of their interaction and the initial phase. ...

A model of macroscale deformation and microvibration in skeletal muscle tissue

Bernd Simeon, Radu Serban, Linda R. Petzold (2009)

ESAIM: Mathematical Modelling and Numerical Analysis

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This paper deals with modeling the passive behavior of skeletal muscle tissue including certain microvibrations at the cell level. Our approach combines a continuum mechanics model with large deformation and incompressibility at the macroscale with chains of coupled nonlinear oscillators. The model verifies that an externally applied vibration at the appropriate frequency is able to synchronize microvibrations in skeletal muscle cells. From the numerical analysis point of view,...

Some tracks in air pollution modelling and simulation.

Bruno Sportisse, Jaouad Boutahar, Edouard Debry, Denis Quélo, Karine Sartelet (2002)

RACSAM

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In this article we discuss some issues related to Air Pollution modelling (as viewed by the authors): subgrid parametrization, multiphase modelling, reduction of high dimensional models and data assimilation. Numerical applications are given with POLAIR, a 3D numerical platform devoted to modelling of atmospheric trace species.

Modeling Pulsatility in the Human Cardiovascular System

de los Reyes V, Aurelio, Kappel, Franz (2010)

Mathematica Balkanica New Series

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AMS Subj. Classification: 92C30 In this study we investigated, modified and combined two existing mathematical cardiovascular models, a non-pulsatile global model and a simplified pulsatile left heart model. The first goal of the study was to integrate these models. The main objective is to have a global lumped parameter pulsatile model that predicts the pressures in the systemic and pulmonary circulation, and specifically the pulsatile pressures in the the finger arteries where...

Role of Dispersion Attraction in Differential Geometry Based Nonpolar Solvation Models

Zhan Chen (2015)

Molecular Based Mathematical Biology

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Differential geometry (DG) based solvation models have shown their great success in solvation analysis by avoiding the use of ad hoc surface definitions, coupling the polar and nonpolar free energies, and generating solvent-solute boundary in a physically self-consistent fashion. Parameter optimization is a key factor for their accuracy, predictive ability of solvation free energies, and other applications. Recently, a series of efforts have been made to improve the parameterization...

Thermodynamics of DNA microarrays

Enrico Carlon (2008)

Banach Center Publications

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DNA microarrays have been widely used in molecular biology laboratories. The main current application of these devices is the determination of the gene expression level for thousands of genes simultaneously. Here we review a recently introduced physical model for hybridization (i.e. the binding of complementary DNA strands) in Affymetrix arrays and compare it to experimental results. The experimental data follow rather well the microscopic model and the approach offers several advantages...

Quantifying the Impact of Bacterial Fitness and Repeated Antimicrobial Exposure on the Emergence of Multidrug-Resistant Gram-Negative Bacilli

E. M.C. D'Agata, M. Horn, G. Webb (2010)

Mathematical Modelling of Natural Phenomena

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The emergence of multidrug resistance among gram-negative bacilli is complex. Numerous factors need to be considered, including the biological fitness cost of resistance, fitnesscompensatory mutations and frequency and type of antibiotic exposure. A mathematical model evaluating these complex relationships was developed in an individual colonized with strains of pan-susceptible, single-, two- and multidrug-resistant (MDR) gram-negative bacilli (GN). The effect of bacterial fitness,...

Modeling and Simulation of Thermo-Fluid-Electrochemical Ion Flow in Biological Channels

Riccardo Sacco, Fabio Manganini, Joseph W. Jerome (2015)

Molecular Based Mathematical Biology

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In this articlewe address the study of ion charge transport in the biological channels separating the intra and extracellular regions of a cell. The focus of the investigation is devoted to including thermal driving forces in the well-known velocity-extended Poisson-Nernst-Planck (vPNP) electrodiffusion model. Two extensions of the vPNP system are proposed: the velocity-extended Thermo-Hydrodynamic model (vTHD) and the velocity-extended Electro-Thermal model (vET). Both formulations...