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In this paper, we investigate the optimal location of secondary sources (controls) to enhance the reduction of the noise field in a one-dimensional acoustic cavity. We first formulate the active control strategy as a linear quadratic tracking (LQT) problem in a Hilbert space, and then formulate the optimization problem as minimizing an appropriate performance criterion based on the LQT cost function with respect to the location of the controls. A numerical scheme based on the Legendre–tau method...
The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicity of an oxaliplatin anti-tumour treatment has been derived. We then applied an optimal control technique...
The chronotherapy concept takes advantage of the circadian rhythm of
cells physiology in maximising a treatment efficacy on its target
while minimising its toxicity on healthy organs. The
object of the present paper is to investigate mathematically and
numerically optimal strategies in cancer chronotherapy. To this
end a mathematical model describing the time evolution of efficiency
and toxicity of an oxaliplatin anti-tumour treatment has been derived.
We then applied an optimal control...
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