Analysis of a Population Model Structured by the Cells Molecular Content

M. Doumic

Mathematical Modelling of Natural Phenomena (2010)

  • Volume: 2, Issue: 3, page 121-152
  • ISSN: 0973-5348

Abstract

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We study the mathematical properties of a general model of cell division structured with several internal variables. We begin with a simpler and specific model with two variables, we solve the eigenvalue problem with strong or weak assumptions, and deduce from it the long-time convergence. The main difficulty comes from natural degeneracy of birth terms that we overcome with a regularization technique. We then extend the results to the case with several parameters and recall the link between this simplified model and the one presented in [6]; an application to the non-linear problem is also given, leading to robust subpolynomial growth of the total population.

How to cite

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Doumic, M.. "Analysis of a Population Model Structured by the Cells Molecular Content." Mathematical Modelling of Natural Phenomena 2.3 (2010): 121-152. <http://eudml.org/doc/222436>.

@article{Doumic2010,
abstract = { We study the mathematical properties of a general model of cell division structured with several internal variables. We begin with a simpler and specific model with two variables, we solve the eigenvalue problem with strong or weak assumptions, and deduce from it the long-time convergence. The main difficulty comes from natural degeneracy of birth terms that we overcome with a regularization technique. We then extend the results to the case with several parameters and recall the link between this simplified model and the one presented in [6]; an application to the non-linear problem is also given, leading to robust subpolynomial growth of the total population.},
author = {Doumic, M.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {structured populations; cell division; relative entropy; long-time asymptotic; eigenproblem; transport equation; transport equation},
language = {eng},
month = {3},
number = {3},
pages = {121-152},
publisher = {EDP Sciences},
title = {Analysis of a Population Model Structured by the Cells Molecular Content},
url = {http://eudml.org/doc/222436},
volume = {2},
year = {2010},
}

TY - JOUR
AU - Doumic, M.
TI - Analysis of a Population Model Structured by the Cells Molecular Content
JO - Mathematical Modelling of Natural Phenomena
DA - 2010/3//
PB - EDP Sciences
VL - 2
IS - 3
SP - 121
EP - 152
AB - We study the mathematical properties of a general model of cell division structured with several internal variables. We begin with a simpler and specific model with two variables, we solve the eigenvalue problem with strong or weak assumptions, and deduce from it the long-time convergence. The main difficulty comes from natural degeneracy of birth terms that we overcome with a regularization technique. We then extend the results to the case with several parameters and recall the link between this simplified model and the one presented in [6]; an application to the non-linear problem is also given, leading to robust subpolynomial growth of the total population.
LA - eng
KW - structured populations; cell division; relative entropy; long-time asymptotic; eigenproblem; transport equation; transport equation
UR - http://eudml.org/doc/222436
ER -

Citations in EuDML Documents

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  1. Sébastien Benzekry, Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers
  2. Sébastien Benzekry, Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers
  3. J. Clairambault, S. Gaubert, Th. Lepoutre, Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models
  4. Sébastien Benzekry, Mathematical and numerical analysis of a model for anti-angiogenic therapy in metastatic cancers
  5. J. Clairambault, Modelling Physiological and Pharmacological Control on Cell Proliferation to Optimise Cancer Treatments

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