Displaying similar documents to “On parameter estimation in the bass model by nonlinear least squares fitting the adoption curve”

Nonparametric instrumental variables for identification of block-oriented systems

Grzegorz Mzyk (2013)

International Journal of Applied Mathematics and Computer Science

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A combined, parametric-nonparametric identification algorithm for a special case of NARMAX systems is proposed. The parameters of individual blocks are aggregated in one matrix (including mixed products of parameters). The matrix is estimated by an instrumental variables technique with the instruments generated by a nonparametric kernel method. Finally, the result is decomposed to obtain parameters of the system elements. The consistency of the proposed estimate is proved and the rate...

Numerical optimization of parameters in systems of differential equations

Martínek, Josef, Kučera, Václav

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We present results on the estimation of unknown parameters in systems of ordinary differential equations in order to fit the output of models to real data. The numerical method is based on the nonlinear least squares problem along with the solution of sensitivity equations corresponding to the differential equations. We will present the performance of the method on the problem of fitting the output of basic compartmental epidemic models to data from the Covid-19 epidemic. This allows...

On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy

Jurjen Duintjer Tebbens, Ctirad Matonoha, Andreas Matthios, Štěpán Papáček (2019)

Applications of Mathematics

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A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence...

Numerical studies of parameter estimation techniques for nonlinear evolution equations

Azmy S. Ackleh, Robert R. Ferdinand, Simeon Reich (1998)

Kybernetika

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We briefly discuss an abstract approximation framework and a convergence theory of parameter estimation for a general class of nonautonomous nonlinear evolution equations. A detailed discussion of the above theory has been given earlier by the authors in another paper. The application of this theory together with numerical results indicating the feasibility of this general least squares approach are presented in the context of quasilinear reaction diffusion equations.