Displaying similar documents to “Identification of parametric models with a priori knowledge of process properties”

On parameter estimation in an in vitro compartmental model for drug-induced enzyme production in pharmacotherapy

Jurjen Duintjer Tebbens, Ctirad Matonoha, Andreas Matthios, Štěpán Papáček (2019)

Applications of Mathematics

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A pharmacodynamic model introduced earlier in the literature for in silico prediction of rifampicin-induced CYP3A4 enzyme production is described and some aspects of the involved curve-fitting based parameter estimation are discussed. Validation with our own laboratory data shows that the quality of the fit is particularly sensitive with respect to an unknown parameter representing the concentration of the nuclear receptor PXR (pregnane X receptor). A detailed analysis of the influence...

Set-membership identifiability of nonlinear models and related parameter estimation properties

Carine Jauberthie, Louise Travé-Massuyès, Nathalie Verdière (2016)

International Journal of Applied Mathematics and Computer Science

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Identifiability guarantees that the mathematical model of a dynamic system is well defined in the sense that it maps unambiguously its parameters to the output trajectories. This paper casts identifiability in a set-membership (SM) framework and relates recently introduced properties, namely, SM-identifiability, μ-SM-identifiability, and ε-SM-identifiability, to the properties of parameter estimation problems. Soundness and ε-consistency are proposed to characterize these problems and...

Modeling the Dynamics of the Cardiovascular-respiratory System (CVRS) in Humans, a Survey

F. Kappel (2012)

Mathematical Modelling of Natural Phenomena

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In this paper we give a survey on modeling efforts concerning the CVRS. The material we discuss is organized in accordance with modeling goals and stresses control and transport issues. We also address basic modeling approaches and discuss some of the challenges for mathematical modeling methodologies in the context of parameter estimation and model validation.

A Galerkin strategy with Proper Orthogonal Decomposition for parameter-dependent problems – Analysis, assessments and applications to parameter estimation

D. Chapelle, A. Gariah, P. Moireau, J. Sainte-Marie (2013)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

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We address the issue of parameter variations in POD approximations of time-dependent problems, without any specific restriction on the form of parameter dependence. Considering a parabolic model problem, we propose a POD construction strategy allowing us to obtain some error estimates controlled by the POD remainder – in the construction procedure – and some parameter-wise interpolation errors for the model solutions. We provide a thorough numerical assessment of this strategy with the...

Some Parameter Estimation Issues in Functional-Structural Plant Modelling

P.-H. Cournède, V. Letort, A. Mathieu, M. Z. Kang, S. Lemaire, S. Trevezas, F. Houllier, P. de Reffye (2011)

Mathematical Modelling of Natural Phenomena

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The development of functional-structural plant models has opened interesting perspectives for a better understanding of plant growth as well as for potential applications in breeding or decision aid in farm management. Parameterization of such models is however a difficult issue due to the complexity of the involved biological processes and the interactions between these processes. The estimation of parameters from experimental data by...

Set membership estimation of parameters and variables in dynamic networks by recursive algorithms with a moving measurement window

Kazimierz Duzinkiewicz (2006)

International Journal of Applied Mathematics and Computer Science

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The paper considers a set membership joint estimation of variables and parameters in complex dynamic networks based on parametric uncertain models and limited hard measurements. A recursive estimation algorithm with a moving measurement window is derived that is suitable for on-line network monitoring. The window allows stabilising the classic recursive estimation algorithm and significantly improves estimate tightness. The estimator is validated on a case study regarding a water distribution...