In nonlinear regression models with constraints a linearization of the model leads to a bias in estimators of parameters of the mean value of the observation vector. Some criteria how to recognize whether a linearization is possible is developed. In the case that they are not satisfied, it is necessary to decide whether some quadratic corrections can make the estimator better. The aim of the paper is to contribute to the solution of the problem.

A linearization of the nonlinear regression model causes a bias in estimators of model parameters. It can be eliminated, e.g., either by a proper choice of the point where the model is developed into the Taylor series or by quadratic corrections of linear estimators. The aim of the paper is to obtain formulae for biases and variances of estimators in linearized models and also for corrected estimators.

The aim of the paper is to estimate a function $\gamma =tr\left(D\beta {\beta }^{\text{'}}\right)+tr(C\sum )$ (with $d,C$ known matrices) in a regression model $(Y,X\beta ,\sum )$ with an unknown parameter $\beta$ and covariance matrix $\sum$. Stochastically independent replications $Y_1,...,Y_m$ of the stochastic vector $Y$ are considered, where the estimators of $X\beta$ and $\sum$ are $\overline{Y}=\frac{1}{m}{\sum }_{i=1}^m{Y}_i$ and $\widehat{\sum }={(m-1)}^{-1}{\sum }_{i=1}^m(Y_i-\overline{Y}){(Y_i-\overline{Y})}^{\text{'}}$, respectively. Locally and uniformly best inbiased estimators of the function $\gamma$, based on $\overline{Y}$ and $\widehat{\sum }$, are given.