We define and characterize weak and strong two-scale convergence in Lp, C0 and other spaces via a transformation of variable, extending Nguetseng's definition. We derive several properties, including weak and strong two-scale compactness; in particular we prove two-scale versions of theorems of Ascoli-Arzelà, Chacon, Riesz, and Vitali. We then approximate two-scale derivatives, and define two-scale convergence in spaces of either weakly or strongly differentiable functions. We also derive...