Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling

G. Bocharov; V. Chereshnev; I. Gainova; S. Bazhan; B. Bachmetyev; J. Argilaguet; J. Martinez; A. Meyerhans

Mathematical Modelling of Natural Phenomena (2012)

  • Volume: 7, Issue: 5, page 78-104
  • ISSN: 0973-5348


HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis.

How to cite


Bocharov, G., et al. "Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling." Mathematical Modelling of Natural Phenomena 7.5 (2012): 78-104. <>.

abstract = {HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis.},
author = {Bocharov, G., Chereshnev, V., Gainova, I., Bazhan, S., Bachmetyev, B., Argilaguet, J., Martinez, J., Meyerhans, A.},
journal = {Mathematical Modelling of Natural Phenomena},
keywords = {mathematical modelling; host–pathogen interaction; immune system; human immunodeficiency virus infection; host-pathogen interaction},
language = {eng},
month = {10},
number = {5},
pages = {78-104},
publisher = {EDP Sciences},
title = {Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling},
url = {},
volume = {7},
year = {2012},

AU - Bocharov, G.
AU - Chereshnev, V.
AU - Gainova, I.
AU - Bazhan, S.
AU - Bachmetyev, B.
AU - Argilaguet, J.
AU - Martinez, J.
AU - Meyerhans, A.
TI - Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling
JO - Mathematical Modelling of Natural Phenomena
DA - 2012/10//
PB - EDP Sciences
VL - 7
IS - 5
SP - 78
EP - 104
AB - HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii) can one modify the dynamic equilibrium for host benefit? (iii) can one predict the outcome of a system perturbation via antiviral drugs or drugs modulating the host immune response dynamics? Answering these questions requires a major interdisciplinary effort, and in particular, the development of novel mathematical approaches for a coherent quantitative description and prediction of intra-patient HIV evolution, the immunological responses to HIV infection, and the systems level homeostatic regulation of specific effector and regulatory lymphocyte populations in correlation with disease status. Here we summarized fundamental biological features of HIV infection and current mathematical modelling attempts to understand HIV pathogenesis.
LA - eng
KW - mathematical modelling; host–pathogen interaction; immune system; human immunodeficiency virus infection; host-pathogen interaction
UR -
ER -


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