# A Cost-Effectiveness-Assessing Model of Vaccination for Varicella and Zoster

M. Comba; S. Martorano-Raimundo; E. Venturino

Mathematical Modelling of Natural Phenomena (2012)

- Volume: 7, Issue: 3, page 62-77
- ISSN: 0973-5348

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topComba, M., Martorano-Raimundo, S., and Venturino, E.. "A Cost-Effectiveness-Assessing Model of Vaccination for Varicella and Zoster." Mathematical Modelling of Natural Phenomena 7.3 (2012): 62-77. <http://eudml.org/doc/222352>.

@article{Comba2012,

abstract = {A decision analytical model is presented and analysed to assess the effectiveness and
cost-effectiveness of routine vaccination against varicella and herpes-zoster, or
shingles. These diseases have as common aetiological agent the varicella-zoster virus
(VZV). Zoster can more likely occur in aged people with declining cell-mediated immunity.
The general concern is that universal varicella vaccination might lead to more cases of
zoster: with more vaccinated children exposure of the general population to varicella
infectives become smaller and thus a larger proportion of older people will have weaker
immunity to VZV, leading to more cases of reactivation of zoster. Our compartment model
shows that only two possible equilibria exist, one without varicella and the other one
where varicella and zoster both thrive. Threshold quantities to distinguish these cases
are derived. Cost estimates on a possible herd vaccination program are discussed
indicating a possible tradeoff choice.},

author = {Comba, M., Martorano-Raimundo, S., Venturino, E.},

journal = {Mathematical Modelling of Natural Phenomena},

keywords = {varicella zoster virus; vaccine; cost-effectiveness; epidemics},

language = {eng},

month = {6},

number = {3},

pages = {62-77},

publisher = {EDP Sciences},

title = {A Cost-Effectiveness-Assessing Model of Vaccination for Varicella and Zoster},

url = {http://eudml.org/doc/222352},

volume = {7},

year = {2012},

}

TY - JOUR

AU - Comba, M.

AU - Martorano-Raimundo, S.

AU - Venturino, E.

TI - A Cost-Effectiveness-Assessing Model of Vaccination for Varicella and Zoster

JO - Mathematical Modelling of Natural Phenomena

DA - 2012/6//

PB - EDP Sciences

VL - 7

IS - 3

SP - 62

EP - 77

AB - A decision analytical model is presented and analysed to assess the effectiveness and
cost-effectiveness of routine vaccination against varicella and herpes-zoster, or
shingles. These diseases have as common aetiological agent the varicella-zoster virus
(VZV). Zoster can more likely occur in aged people with declining cell-mediated immunity.
The general concern is that universal varicella vaccination might lead to more cases of
zoster: with more vaccinated children exposure of the general population to varicella
infectives become smaller and thus a larger proportion of older people will have weaker
immunity to VZV, leading to more cases of reactivation of zoster. Our compartment model
shows that only two possible equilibria exist, one without varicella and the other one
where varicella and zoster both thrive. Threshold quantities to distinguish these cases
are derived. Cost estimates on a possible herd vaccination program are discussed
indicating a possible tradeoff choice.

LA - eng

KW - varicella zoster virus; vaccine; cost-effectiveness; epidemics

UR - http://eudml.org/doc/222352

ER -

## References

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