Mathematically Modelling The Dissolution Of Solid Dispersions

Meere, Martin; McGinty, Sean; Pontrelli, Giuseppe

  • Proceedings of Equadiff 14, Publisher: Slovak University of Technology in Bratislava, SPEKTRUM STU Publishing(Bratislava), page 341-348

Abstract

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A solid dispersion is a dosage form in which an active ingredient (a drug) is mixed with at least one inert solid component. The purpose of the inert component is usually to improve the bioavailability of the drug. In particular, the inert component is frequently chosen to improve the dissolution rate of a drug that is poorly soluble in water. The construction of reliable mathematical models that accurately describe the dissolution of solid dispersions would clearly assist with their rational design. However, the development of such models is challenging since a dissolving solid dispersion constitutes a non-ideal mixture, and the selection of appropriate forms for the activity coefficients that describe the interaction between the drug, the inert matrix, and the dissolution medium is delicate. In this paper, we present some preliminary ideas for modelling the dissolution of solid dispersions.

How to cite

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Meere, Martin, McGinty, Sean, and Pontrelli, Giuseppe. "Mathematically Modelling The Dissolution Of Solid Dispersions." Proceedings of Equadiff 14. Bratislava: Slovak University of Technology in Bratislava, SPEKTRUM STU Publishing, 2017. 341-348. <http://eudml.org/doc/294925>.

@inProceedings{Meere2017,
abstract = {A solid dispersion is a dosage form in which an active ingredient (a drug) is mixed with at least one inert solid component. The purpose of the inert component is usually to improve the bioavailability of the drug. In particular, the inert component is frequently chosen to improve the dissolution rate of a drug that is poorly soluble in water. The construction of reliable mathematical models that accurately describe the dissolution of solid dispersions would clearly assist with their rational design. However, the development of such models is challenging since a dissolving solid dispersion constitutes a non-ideal mixture, and the selection of appropriate forms for the activity coefficients that describe the interaction between the drug, the inert matrix, and the dissolution medium is delicate. In this paper, we present some preliminary ideas for modelling the dissolution of solid dispersions.},
author = {Meere, Martin, McGinty, Sean, Pontrelli, Giuseppe},
booktitle = {Proceedings of Equadiff 14},
keywords = {Solid Dispersion, Mathematical Model, Partial Differential Equations, Activity Coefficients},
location = {Bratislava},
pages = {341-348},
publisher = {Slovak University of Technology in Bratislava, SPEKTRUM STU Publishing},
title = {Mathematically Modelling The Dissolution Of Solid Dispersions},
url = {http://eudml.org/doc/294925},
year = {2017},
}

TY - CLSWK
AU - Meere, Martin
AU - McGinty, Sean
AU - Pontrelli, Giuseppe
TI - Mathematically Modelling The Dissolution Of Solid Dispersions
T2 - Proceedings of Equadiff 14
PY - 2017
CY - Bratislava
PB - Slovak University of Technology in Bratislava, SPEKTRUM STU Publishing
SP - 341
EP - 348
AB - A solid dispersion is a dosage form in which an active ingredient (a drug) is mixed with at least one inert solid component. The purpose of the inert component is usually to improve the bioavailability of the drug. In particular, the inert component is frequently chosen to improve the dissolution rate of a drug that is poorly soluble in water. The construction of reliable mathematical models that accurately describe the dissolution of solid dispersions would clearly assist with their rational design. However, the development of such models is challenging since a dissolving solid dispersion constitutes a non-ideal mixture, and the selection of appropriate forms for the activity coefficients that describe the interaction between the drug, the inert matrix, and the dissolution medium is delicate. In this paper, we present some preliminary ideas for modelling the dissolution of solid dispersions.
KW - Solid Dispersion, Mathematical Model, Partial Differential Equations, Activity Coefficients
UR - http://eudml.org/doc/294925
ER -

References

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