Identification of hysteric control influence operators representing smart actuators. I: Formulation.
Perturbation of strongly continuous cosine family generators
Quantifying the Impact of Bacterial Fitness and Repeated Antimicrobial Exposure on the Emergence of Multidrug-Resistant Gram-Negative Bacilli
The emergence of multidrug resistance among gram-negative bacilli is complex. Numerous factors need to be considered, including the biological fitness cost of resistance, fitnesscompensatory mutations and frequency and type of antibiotic exposure. A mathematical model evaluating these complex relationships was developed in an individual colonized with strains of pan-susceptible, single-, two- and multidrug-resistant (MDR) gram-negative bacilli (GN). The effect of bacterial fitness, compensatory...
A Spatial Model of Tumor Growth with Cell Age, Cell Size, and Mutation of Cell Phenotypes
A model of tumor growth in a spatial environment is analyzed. The model includes proliferating and quiescent compartments of tumor cells indexed by successively mutated cell phenotypes of increasingly proliferative aggressiveness. The model incorporates spatial dependence due to both random motility and directed movement haptotaxis. The model structures tumor cells by both cell age and cell size. The model consists of a system of nonlinear partial differential equations for the compartments of...
Global Existence and Boundedness of Solutions to a Model of Chemotaxis
A model of chemotaxis is analyzed that prevents blow-up of solutions. The model consists of a system of nonlinear partial differential equations for the spatial population density of a species and the spatial concentration of a chemoattractant in -dimensional space. We prove the existence of solutions, which exist globally, and are -bounded on finite time intervals. The hypotheses require nonlocal conditions on the species-induced production of the chemoattractant.
Rapid Emergence of Co-colonization with Community-acquired and Hospital-Acquired Methicillin-Resistant Strains in the Hospital Setting
Pre-symptomatic Influenza Transmission, Surveillance, and School Closings: Implications for Novel Influenza A (H1N1)
Early studies of the novel swine-origin 2009 influenza A (H1N1) epidemic indicate clinical attack rates in children much higher than in adults. Non-medical interventions such as school closings are constrained by their large socio-economic costs. Here we develop a mathematical model to ascertain the roles of pre-symptomatic influenza transmission as well as symptoms surveillance of children to assess the utility of school closures. Our model analysis...
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