The cancer stem cell hypothesis has evolved to one of the most important paradigms in biomedical research. During recent years evidence has been accumulating for the existence of stem cell-like populations in different cancers, especially in leukemias. In the current work we propose a mathematical model of cancer stem cell dynamics in leukemias. We apply the model to compare cellular properties of leukemic stem cells to those of their benign counterparts....

We show that dynamical systems in inverse problems are sometimes foliated if the embedding dimension is greater than the dimension of the manifold on which the system resides. Under this condition, we end up reaching different leaves of the foliation if we start from different initial conditions. For some of these cases we have found a method by which we can asymptotically guide the system to a specific leaf even if we start from an initial condition which corresponds to some other leaf. We demonstrate...