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Measuring the Irreversibility of Numerical Schemes for Reversible Stochastic Differential Equations

Markos Katsoulakis, Yannis Pantazis, Luc Rey-Bellet (2014)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

For a stationary Markov process the detailed balance condition is equivalent to the time-reversibility of the process. For stochastic differential equations (SDE’s), the time discretization of numerical schemes usually destroys the time-reversibility property. Despite an extensive literature on the numerical analysis for SDE’s, their stability properties, strong and/or weak error estimates, large deviations and infinite-time estimates, no quantitative results are known on the lack of reversibility...

Modeling the Cancer Stem Cell Hypothesis

C. Calmelet, A. Prokop, J. Mensah, L. J. McCawley, P. S. Crooke (2010)

Mathematical Modelling of Natural Phenomena

Solid tumors and hematological cancers contain small population of tumor cells that are believed to play a critical role in the development and progression of the disease. These cells, named Cancer Stem Cells (CSCs), have been found in leukemia, myeloma, breast, prostate, pancreas, colon, brain and lung cancers. It is also thought that CSCs drive the metastatic spread of cancer. The CSC compartment features a specific and phenotypically defined cell...

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