A local version of the generalized retract theorem of Ważewski with applications in the theory of partial differential equations of first order
We generalize to higher dimension results of Birkhoff and Mather on the existence of orbits wandering in regions of instability of twist maps. This generalization is strongly inspired by the one proposed by Mather. However, its advantage is that it contains most of the results of Birkhoff and Mather on twist maps.
The present paper introduces a tumor model with two time scales, the time t during which the tumor grows and the cycle time of individual cells. The model also includes the effects of gene mutations on the population density of the tumor cells. The model is formulated as a free boundary problem for a coupled system of elliptic, parabolic and hyperbolic equations within the tumor region, with nonlinear and nonlocal terms. Existence and uniqueness theorems are proved, and properties of the free boundary...