A four-dimensional hyperchaotic Lü system with multiple time-delay controllers is considered in this paper. Based on the theory of Hopf bifurcation in delay system, we obtain a simple relationship between the parameters when the system has a periodic solution. Numerical simulations show that the assumption is a rational condition, choosing parameter in the determined region can control hyperchaotic Lü system well, the chaotic state is transformed to the periodic orbit. Finally, we consider the differences...