Let $\mathscr{H}$ be a complex Hilbert space, $A$ a positive operator with closed range in $ℬ\left(\mathscr{H}\right)$ and ${ℬ}_A\left(\mathscr{H}\right)$ the sub-algebra of $ℬ\left(\mathscr{H}\right)$ of all $A$-self-adjoint operators. Assume $\phi :{ℬ}_A\left(\mathscr{H}\right)$ onto itself is a linear continuous map. This paper shows that if $\phi$ preserves $A$-unitary operators such that $\phi \left(I\right)=P$ then $\psi$ defined by $\psi \left(T\right)=P\phi \left(PT\right)$ is a homomorphism or an anti-homomorphism and $\psi \left(T^{♯}\right)=\psi {\left(T\right)}^{♯}$ for all $T\in {ℬ}_A\left(\mathscr{H}\right)$, where $P=A^{+}A$ and $A^{+}$ is the Moore-Penrose inverse of $A$. A similar result is also true if $\phi$ preserves $A$-quasi-unitary operators in both directions such that there exists an...