Let $X$ be a (generalized) flag manifold of a complex semisimple Lie group $G$. We investigate the problem of constructing a graded star product on $ℛ=R\left(T^{☆}X\right)$ which corresponds to a $G$-equivariant quantization of symbols into twisted differential operators acting on half-forms on $X$. We construct, when $ℛ$ is generated by the momentum functions ${\mu }^x$ for $G$, a preferred choice of $☆$ where ${\mu }^x☆\phi$ has the form ${\mu }^x\phi +\frac{1}{2}\{{\mu }^x,\phi \}t+{\Lambda }^x\left(\phi \right)t^2$. Here ${\Lambda }^x$ are operators on $ℛ$. In the known examples, ${\Lambda }^x$ ($x\ne 0$) is not a differential operator, and so the star product ${\mu }^x☆\phi$...