In topology optimization problems, we are often forced to deal with large-scale numerical problems, so that the domain decomposition method occurs naturally. Consider a typical topology optimization problem, the minimum compliance problem of a linear isotropic elastic continuum structure, in which the constraints are the partial differential equations of linear elasticity. We subdivide the partial differential equations into two subproblems posed...

The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production...