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Cell-to-muscle homogenization. Application to a constitutive law for the myocardium

Denis Caillerie, Ayman Mourad, Annie Raoult (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We derive a constitutive law for the myocardium from the description of both the geometrical arrangement of cardiomyocytes and their individual mechanical behaviour. We model a set of cardiomyocytes by a quasiperiodic discrete lattice of elastic bars interacting by means of moments. We work in a large displacement framework and we use a discrete homogenization technique. The macroscopic constitutive law is obtained through the resolution of a nonlinear self-equilibrum system of the discrete lattice...

Cell-to-Muscle homogenization. Application to a constitutive law for the myocardium

Denis Caillerie, Ayman Mourad, Annie Raoult (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

We derive a constitutive law for the myocardium from the description of both the geometrical arrangement of cardiomyocytes and their individual mechanical behaviour. We model a set of cardiomyocytes by a quasiperiodic discrete lattice of elastic bars interacting by means of moments. We work in a large displacement framework and we use a discrete homogenization technique. The macroscopic constitutive law is obtained through the resolution of a nonlinear self-equilibrum system of the discrete lattice...

Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models

J. Clairambault, S. Gaubert, Th. Lepoutre (2009)

Mathematical Modelling of Natural Phenomena

We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks, known to exert their influence on the cell division cycle. We compare the growth rate of the model controlled by a time-periodic control on its coefficients with the growth rate of stationary models of the same nature, but with averaged coefficients....

Comparison of supervised learning methods for spike time coding in spiking neural networks

Andrzej Kasiński, Filip Ponulak (2006)

International Journal of Applied Mathematics and Computer Science

In this review we focus our attention on supervised learning methods for spike time coding in Spiking Neural Networks (SNNs). This study is motivated by recent experimental results regarding information coding in biological neural systems, which suggest that precise timing of individual spikes may be essential for efficient computation in the brain. We are concerned with the fundamental question: What paradigms of neural temporal coding can be implemented with the recent learning methods? In order...

Compartmental Models of Migratory Dynamics

J. Knisley, T. Schmickl, I. Karsai (2011)

Mathematical Modelling of Natural Phenomena

Compartmentalization is a general principle in biological systems which is observable on all size scales, ranging from organelles inside of cells, cells in histology, and up to the level of groups, herds, swarms, meta-populations, and populations. Compartmental models are often used to model such phenomena, but such models can be both highly nonlinear and difficult to work with.Fortunately, there are many significant biological systems that are amenable to linear compartmental models which are often...

Convergence analysis for principal component flows

Shintaro Yoshizawa, Uwe Helmke, Konstantin Starkov (2001)

International Journal of Applied Mathematics and Computer Science

A common framework for analyzing the global convergence of several flows for principal component analysis is developed. It is shown that flows proposed by Brockett, Oja, Xu and others are all gradient flows and the global convergence of these flows to single equilibrium points is established. The signature of the Hessian at each critical point is determined.

Could changes in national tuberculosis vaccination policies be ill-informed ?

D.J. Gerberry, F.A. Milner (2012)

Mathematical Modelling of Natural Phenomena

National policies regarding the BCG vaccine for tuberculosis vary greatly throughout the international community and several countries are currently considering discontinuing universal vaccination. Detractors of BCG point to its uncertain effectiveness and its interference with the detection and treatment of latent tuberculosis infection (LTBI). In order to quantify the trade-off between vaccination and treatment of LTBI, a mathematical model was designed and calibrated to data from Brazil, Ghana,...

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