This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem (3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem in distribution logistics. The problem requires the combinatorial optimization of a feasible loading solution and a successive routing of vehicles to satisfy client demands, where all vehicles must start and terminate at a central depot. In spite of its clear practical significance...

This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem (3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem in distribution logistics. The problem requires the combinatorial optimization of a feasible loading solution and a successive routing of vehicles to satisfy client demands, where all vehicles must start and terminate at a central depot. In spite of its clear practical significance...

The invasive capability is fundamental in determining the malignancy of a solid tumor. Revealing biomedical strategies that are able to partially decrease cancer invasiveness is therefore an important approach in the treatment of the disease and has given rise to multiple in vitro and in silico models. We here develop a hybrid computational framework, whose aim is to characterize the effects of the different cellular and subcellular mechanisms involved...

Maintaining liquid asset portfolios involves a high carry cost and is mandatory by law for most financial institutions. Taking this into account a financial institution's aim is to manage a liquid asset portfolio in an “optimal” way, such that it keeps the minimum required liquid assets to comply with regulations. In this paper we propose a multi-stage dynamic stochastic programming model for liquid asset portfolio management. The model allows for portfolio rebalancing decisions over a multi-period...

The question, how does an organism maintain balance? provides a unifying theme to introduce undergraduate students to the use of mathematics and modeling techniques in biological research. The availability of inexpensive high speed motion capture cameras makes it possible to collect the precise and reliable data that facilitates the development of relevant mathematical models. An in–house laboratory component ensures that students have the opportunity...