### 25 let modernizačního hnutí ve školské matematice

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This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem (3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem in distribution logistics. The problem requires the combinatorial optimization of a feasible loading solution and a successive routing of vehicles to satisfy client demands, where all vehicles must start and terminate at a central depot. In spite of its clear practical significance...

The invasive capability is fundamental in determining the malignancy of a solid tumor. Revealing biomedical strategies that are able to partially decrease cancer invasiveness is therefore an important approach in the treatment of the disease and has given rise to multiple in vitro and in silico models. We here develop a hybrid computational framework, whose aim is to characterize the effects of the different cellular and subcellular mechanisms involved...

Computers have been employed in education for years. They help to provide educational aids using multimedia forms such as films, pictures, interactive tasks in the learning process, automated testing, etc. In this paper, a concept of an intelligent e-learning system will be proposed. The main purpose of this system is to teach effectively by providing an optimal learning path in each step of the educational process. The determination of a suitable learning path depends on the student's preferences,...

In current textbooks the use of Chebyshev nodes with Newton interpolation is advocated as the most efficient numerical interpolation method in terms of approximation accuracy and computational effort. However, we show numerically that the approximation quality obtained by Newton interpolation with Fast Leja (FL) points is competitive to the use of Chebyshev nodes, even for extremely high degree interpolation. This is an experimental account of the analytic result that the limit distribution of FL...

As said by Mareš and Mesiar, necessity of aggregation of complex real inputs appears almost in any field dealing with observed (measured) real quantities (see the citation below). For aggregation of probability distributions Sklar designed his copulas as early as in 1959. But surprisingly, since that time only a very few literature have appeared dealing with possibility to aggregate several different pairwise dependencies into one multivariate copula. In the present paper this problem is tackled...

Maintaining liquid asset portfolios involves a high carry cost and is mandatory by law for most financial institutions. Taking this into account a financial institution's aim is to manage a liquid asset portfolio in an “optimal” way, such that it keeps the minimum required liquid assets to comply with regulations. In this paper we propose a multi-stage dynamic stochastic programming model for liquid asset portfolio management. The model allows for portfolio rebalancing decisions over a multi-period...

The question, how does an organism maintain balance? provides a unifying theme to introduce undergraduate students to the use of mathematics and modeling techniques in biological research. The availability of inexpensive high speed motion capture cameras makes it possible to collect the precise and reliable data that facilitates the development of relevant mathematical models. An in–house laboratory component ensures that students have the opportunity...

We extend the classical empirical interpolation method [M. Barrault, Y. Maday, N.C. Nguyen and A.T. Patera, An empirical interpolation method: application to efficient reduced-basis discretization of partial differential equations. Compt. Rend. Math. Anal. Num. 339 (2004) 667–672] to a weighted empirical interpolation method in order to approximate nonlinear parametric functions with weighted parameters, e.g. random variables obeying various probability distributions. A priori convergence analysis...