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A hybrid genetic algorithm for the vehicle routing problem with three-dimensional loading constraints

Lixin Miao, Qingfang Ruan, Kevin Woghiren, Qi Ruo (2012)

RAIRO - Operations Research

This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem (3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem in distribution logistics. The problem requires the combinatorial optimization of a feasible loading solution and a successive routing of vehicles to satisfy client demands, where all vehicles must start and terminate at a central depot. In spite of its clear practical significance...

A hybrid genetic algorithm for the vehicle routing problem with three-dimensional loading constraints

Lixin Miao, Qingfang Ruan, Kevin Woghiren, Qi Ruo (2012)

RAIRO - Operations Research

This paper addresses a Three-Dimensional Loading Capacitated Vehicle Routing Problem (3L-CVRP) which combines a three-dimensional loading problem and vehicle routing problem in distribution logistics. The problem requires the combinatorial optimization of a feasible loading solution and a successive routing of vehicles to satisfy client demands, where all vehicles must start and terminate at a central depot. In spite of its clear practical significance...

A Hybrid Model Describing Different Morphologies of Tumor Invasion Fronts

M. Scianna, L. Preziosi (2012)

Mathematical Modelling of Natural Phenomena

The invasive capability is fundamental in determining the malignancy of a solid tumor. Revealing biomedical strategies that are able to partially decrease cancer invasiveness is therefore an important approach in the treatment of the disease and has given rise to multiple in vitro and in silico models. We here develop a hybrid computational framework, whose aim is to characterize the effects of the different cellular and subcellular mechanisms involved...

A stochastic programming approach to managing liquid asset portfolios

Helgard Raubenheimer, Machiel F. Kruger (2010)

Kybernetika

Maintaining liquid asset portfolios involves a high carry cost and is mandatory by law for most financial institutions. Taking this into account a financial institution's aim is to manage a liquid asset portfolio in an “optimal” way, such that it keeps the minimum required liquid assets to comply with regulations. In this paper we propose a multi-stage dynamic stochastic programming model for liquid asset portfolio management. The model allows for portfolio rebalancing decisions over a multi-period...

A Team Approach to Undergraduate Research in Biomathematics: Balance Control

J. Milton, A. Radunskaya, W. Ou, T. Ohira (2011)

Mathematical Modelling of Natural Phenomena

The question, how does an organism maintain balance? provides a unifying theme to introduce undergraduate students to the use of mathematics and modeling techniques in biological research. The availability of inexpensive high speed motion capture cameras makes it possible to collect the precise and reliable data that facilitates the development of relevant mathematical models. An in–house laboratory component ensures that students have the opportunity...

Building Mathematical Models and Biological Insight in an Introductory Biology Course

A. E. Weisstein (2011)

Mathematical Modelling of Natural Phenomena

A growing body of literature testifies to the importance of quantitative reasoning skills in the 21st-century biology curriculum, and to the learning benefits associated with active pedagogies. The process of modeling a biological system provides an approach that integrates mathematical skills and higher-order thinking with existing course content knowledge. We describe a general strategy for teaching model-building in an introductory biology course,...

Compartmental Models of Migratory Dynamics

J. Knisley, T. Schmickl, I. Karsai (2011)

Mathematical Modelling of Natural Phenomena

Compartmentalization is a general principle in biological systems which is observable on all size scales, ranging from organelles inside of cells, cells in histology, and up to the level of groups, herds, swarms, meta-populations, and populations. Compartmental models are often used to model such phenomena, but such models can be both highly nonlinear and difficult to work with.Fortunately, there are many significant biological systems that are amenable to linear compartmental models which are often...

Drugs in the Classroom: Using Pharmacokinetics to Introduce Biomathematical Modeling

G. A. Koch-Noble (2011)

Mathematical Modelling of Natural Phenomena

Pharmacokinetics is an excellent way to introduce biomathematical modeling at the sophomore level. Students have the opportunity to develop a mathematical model of a biological phenomenon to which they all can relate. Exploring pharmacokinetics takes students through the necessary stages of mathematical modeling: determining the goals of the model, deciphering between the biological aspects to include in the model, defining the assumptions of the model, and finally, building, analyzing, using, and...

Equilibrium search model with endogenous growth rate of human capital

Wansheng Tang, Chi Zhou, Chaoqun Xiao, Ruiqing Zhao (2016)

Kybernetika

This article studies an equilibrium search problem when jobs provided by firms can be either unskilled or skilled and when workers differing in their education level can be either low-educated or high-educated. The structure proportion of jobs affects the equilibrium which indicates a threshold that can distinguish whether the equilibrium is separating or cross-skill. In addition, the cross-skill equilibrium solution implies the high-educated workers are more likely to obtain higher pay rates than...

Food Webs, Competition Graphs, and Habitat Formation

M. Cozzens (2011)

Mathematical Modelling of Natural Phenomena

One interesting example of a discrete mathematical model used in biology is a food web. The first biology courses in high school and in college present the fundamental nature of a food web, one that is understandable by students at all levels. But food webs as part of a larger system are often not addressed. This paper presents materials that can be used in undergraduate classes in biology (and mathematics) and provides students with the opportunity...

Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling

G. Bocharov, V. Chereshnev, I. Gainova, S. Bazhan, B. Bachmetyev, J. Argilaguet, J. Martinez, A. Meyerhans (2012)

Mathematical Modelling of Natural Phenomena

HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii)...

Integrating Photosynthesis, Respiration, Biomass Partitioning, and Plant Growth: Developing a Microsoft Excel®-based Simulation Model of Wisconsin Fast Plant (Brassica rapa, Brassicaceae) Growth with Undergraduate Students

Y. L. Grossman, A. B. Berdanier, M. L. Custic, L. R. Feeley, S. F. Peake, A. J. Saenz, K. S. Sitton (2011)

Mathematical Modelling of Natural Phenomena

This paper demonstrates the development of a simple model of carbon flow during plant growth. The model was developed by six undergraduate students and their instructor as a project in a plant ecophysiology course. The paper describes the structure of the model including the equations that were used to implement it in Excel®, the plant growth experiments that were conducted to obtain information for parameterizing and testing the model, model performance, student responses to the modeling project,...

Mathematical Biology Education: Modeling Makes Meaning

J. R. Jungck (2011)

Mathematical Modelling of Natural Phenomena

This special issue of Mathematical Modelling of Natural Phenomena on biomathematics education shares the work of fifteen groups at as many different institutions that have developed beautiful biological applications of mathematics that are different in three ways from much of what is currently available. First, many of these selections utilize current research in biomathematics rather than the well-known textbook examples that are at least a half-century old. Second, the selections focus on modules...

Mathematical Models of Dividing Cell Populations: Application to CFSE Data

H.T. Banks, W. Clayton Thompson (2012)

Mathematical Modelling of Natural Phenomena

Flow cytometric analysis using intracellular dyes such as CFSE is a powerful experimental tool which can be used in conjunction with mathematical modeling to quantify the dynamic behavior of a population of lymphocytes. In this survey we begin by providing an overview of the mathematically relevant aspects of the data collection procedure. We then present an overview of the large body of mathematical models, along with their assumptions and uses,...

Modeling Dryland Landscapes

E. Meron (2010)

Mathematical Modelling of Natural Phenomena

The discovery of nearly periodic vegetation patterns in arid and semi-arid regions motivated numerous model studies in the past decade. Most studies have focused on vegetation pattern formation, and on the response of vegetation patterns to gradients of the limiting water resource. The reciprocal question, what resource modifications are induced by vegetation pattern formation, which is essential to the understanding of dryland landscapes, has hardly...

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