We deal with an optimal control problem with respect to a variable thickness for a dynamic viscoelastic plate with velocity constraints. The state problem has the form of a pseudohyperbolic variational inequality. The existence and uniqueness theorem for the state problem and the existence of an optimal thickness function are proved.
The scheduling of angiogenic inhibitors to control a vascularized tumor is analyzed as an optimal control problem for a mathematical model that was developed and biologically validated by Hahnfeldt et al. [Cancer Res. 59 (1999)]. Two formulations of the problem are considered. In the first one the primary tumor volume is minimized for a given amount of angiogenic inhibitors to be administered, while a balance between tumor reduction and the total amount of angiogenic inhibitors given is minimized...
The scalar nonconvex variational problems of the minimum-energy type on Sobolev spaces are studied. As the Euler–Lagrange equation dramatically looses selectivity when extended in terms of the Young measures, the correct optimality conditions are sought by means of the convex compactification theory. It turns out that these conditions basically combine one part from the Euler–Lagrange equation with one part from the Weierstrass condition.