We first discuss a class of inequalities of Onofri type depending on a parameter, in the two-dimensional Euclidean space. The inequality holds for radial functions if the parameter is larger than $-1$. Without symmetry assumption, it holds if and only if the parameter is in the interval $(-1,0]$. The inequality gives us some insight on the symmetry breaking phenomenon for the extremal functions of the Caffarelli-Kohn-Nirenberg inequality, in two space dimensions. In fact, for suitable sets of parameters (asymptotically...