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New Computational Tools for Modeling Chronic Myelogenous Leukemia

M. M. Peet, P. S. Kim, S.-I. Niculescu, D. Levy (2009)

Mathematical Modelling of Natural Phenomena

In this paper, we consider a system of nonlinear delay-differential equations (DDEs) which models the dynamics of the interaction between chronic myelogenous leukemia (CML), imatinib, and the anti-leukemia immune response. Because of the chaotic nature of the dynamics and the sparse nature of experimental data, we look for ways to use computation to analyze the model without employing direct numerical simulation. In particular, we develop several tools using Lyapunov-Krasovskii analysis that allow...

On stable polynomials

Miloslav Nekvinda (1989)

Aplikace matematiky

The article is a survey on problem of the theorem of Hurwitz. The starting point of explanations is Schur's decomposition theorem for polynomials. It is showed how to obtain the well-known criteria on the distribution of roots of polynomials. The theorem on uniqueness of constants in Schur's decomposition seems to be new.

On the number of zeros of Melnikov functions

Sergey Benditkis, Dmitry Novikov (2011)

Annales de la faculté des sciences de Toulouse Mathématiques

We provide an effective uniform upper bound for the number of zeros of the first non-vanishing Melnikov function of a polynomial perturbations of a planar polynomial Hamiltonian vector field. The bound depends on degrees of the field and of the perturbation, and on the order k of the Melnikov function. The generic case k = 1 was considered by Binyamini, Novikov and Yakovenko [BNY10]. The bound follows from an effective construction of the Gauss-Manin connection for iterated integrals.

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