Mathematical model of dengue disease transmission with severe DHF compartment.
Mean-Field Optimal Control
We introduce the concept of mean-field optimal control which is the rigorous limit process connecting finite dimensional optimal control problems with ODE constraints modeling multi-agent interactions to an infinite dimensional optimal control problem with a constraint given by a PDE of Vlasov-type, governing the dynamics of the probability distribution of interacting agents. While in the classical mean-field theory one studies the behavior of a large number of small individuals freely interacting...
Model of AIDS-related tumour with time delay
We present and compare two simple models of immune system and cancer cell interactions. The first model reflects simple cancer disease progression and serves as our "control" case. The second describes the progression of a cancer disease in the case of a patient infected with the HIV-1 virus.
Modeling schistosomiasis and HIV/AIDS codynamics.
Modeling the Cancer Stem Cell Hypothesis
Solid tumors and hematological cancers contain small population of tumor cells that are believed to play a critical role in the development and progression of the disease. These cells, named Cancer Stem Cells (CSCs), have been found in leukemia, myeloma, breast, prostate, pancreas, colon, brain and lung cancers. It is also thought that CSCs drive the metastatic spread of cancer. The CSC compartment features a specific and phenotypically defined cell...
Modelling the spiders ballooning effect on the vineyard ecology
We consider an ecosystem in which spiders may be transported by the wind from vineyards into the surrounding woods and vice versa. The model takes into account this tranport phenomenon without building space explicitly into the governing equations. The equilibria of the dynamical system are analyzed together with their stability, showing that bifurcations may occur. Then the effects of indiscriminated spraying to keep pests under control is also investigated via suitable simulations.
Modelling Tuberculosis and Hepatitis B Co-infections
Tuberculosis (TB) is the leading cause of death among individuals infected with the hepatitis B virus (HBV). The study of the joint dynamics of HBV and TB present formidable mathematical challenges due to the fact that the models of transmission are quite distinct. We formulate and analyze a deterministic mathematical model which incorporates of the co-dynamics of hepatitis B and tuberculosis. Two sub-models, namely: HBV-only and TB-only sub-models...
Monte Carlo simulation and analytic approximation of epidemic processes on large networks
Low dimensional ODE approximations that capture the main characteristics of SIS-type epidemic propagation along a cycle graph are derived. Three different methods are shown that can accurately predict the expected number of infected nodes in the graph. The first method is based on the derivation of a master equation for the number of infected nodes. This uses the average number of SI edges for a given number of the infected nodes. The second approach is based on the observation that the epidemic...
Multiobjective optimal control of HIV dynamics.
Multistage evolutionary model for carcinogenesis mutations.