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Optimal Control of a Cancer Cell Model with Delay

C. Collins, K.R. Fister, M. Williams (2010)

Mathematical Modelling of Natural Phenomena

In this paper, we look at a model depicting the relationship of cancer cells in different development stages with immune cells and a cell cycle specific chemotherapy drug. The model includes a constant delay in the mitotic phase. By applying optimal control theory, we seek to minimize the cost associated with the chemotherapy drug and to minimize the number of tumor cells. Global existence of a solution has been shown for this model and existence...

Optimal design of cylindrical shells

Peter Nestler, Werner H. Schmidt (2010)

Discussiones Mathematicae, Differential Inclusions, Control and Optimization

The present paper studies an optimization problem of dynamically loaded cylindrical tubes. This is a problem of linear elasticity theory. As we search for the optimal thickness of the tube which minimizes the displacement under forces, this is a problem of shape optimization. The mathematical model is given by a differential equation (ODE and PDE, respectively); the mechanical problem is described as an optimal control problem. We consider both the stationary (time independent) and the transient...

Optimal nonlinear transformations of random variables

Aldo Goia, Ernesto Salinelli (2010)

Annales de l'I.H.P. Probabilités et statistiques

In this paper we deepen the study of the nonlinear principal components introduced by Salinelli in 1998, referring to a real random variable. New insights on their probabilistic and statistical meaning are given with some properties. An estimation procedure based on spline functions, adapting to a statistical framework the classical Rayleigh–Ritz method, is introduced. Asymptotic properties of the estimator are proved, providing an upper bound for the rate of convergence under suitable mild conditions....

Optimal placement of controls for a one-dimensional active noise control problem

Fariba Fahroo (1998)

Kybernetika

In this paper, we investigate the optimal location of secondary sources (controls) to enhance the reduction of the noise field in a one-dimensional acoustic cavity. We first formulate the active control strategy as a linear quadratic tracking (LQT) problem in a Hilbert space, and then formulate the optimization problem as minimizing an appropriate performance criterion based on the LQT cost function with respect to the location of the controls. A numerical scheme based on the Legendre–tau method...

Optimisation of time-scheduled regimen for anti-cancer drug infusion

Claude Basdevant, Jean Clairambault, Francis Lévi (2005)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicity of an oxaliplatin anti-tumour treatment has been derived. We then applied an optimal control technique...

Optimisation of time-scheduled regimen for anti-cancer drug infusion

Claude Basdevant, Jean Clairambault, Francis Lévi (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

The chronotherapy concept takes advantage of the circadian rhythm of cells physiology in maximising a treatment efficacy on its target while minimising its toxicity on healthy organs. The object of the present paper is to investigate mathematically and numerically optimal strategies in cancer chronotherapy. To this end a mathematical model describing the time evolution of efficiency and toxicity of an oxaliplatin anti-tumour treatment has been derived. We then applied an optimal control...

Currently displaying 41 – 60 of 81