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Parameter estimation in non-linear mixed effects models with SAEM algorithm: extension from ODE to PDE

E. Grenier, V. Louvet, P. Vigneaux (2014)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

Parameter estimation in non linear mixed effects models requires a large number of evaluations of the model to study. For ordinary differential equations, the overall computation time remains reasonable. However when the model itself is complex (for instance when it is a set of partial differential equations) it may be time consuming to evaluate it for a single set of parameters. The procedures of population parametrization (for instance using SAEM algorithms) are then very long and in some cases...

Parametric inference for mixed models defined by stochastic differential equations

Sophie Donnet, Adeline Samson (2008)

ESAIM: Probability and Statistics

Non-linear mixed models defined by stochastic differential equations (SDEs) are considered: the parameters of the diffusion process are random variables and vary among the individuals. A maximum likelihood estimation method based on the Stochastic Approximation EM algorithm, is proposed. This estimation method uses the Euler-Maruyama approximation of the diffusion, achieved using latent auxiliary data introduced to complete the diffusion process between each pair of measurement instants. A tuned...

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