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Cell-to-muscle homogenization. Application to a constitutive law for the myocardium

Denis Caillerie, Ayman Mourad, Annie Raoult (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We derive a constitutive law for the myocardium from the description of both the geometrical arrangement of cardiomyocytes and their individual mechanical behaviour. We model a set of cardiomyocytes by a quasiperiodic discrete lattice of elastic bars interacting by means of moments. We work in a large displacement framework and we use a discrete homogenization technique. The macroscopic constitutive law is obtained through the resolution of a nonlinear self-equilibrum system of the discrete lattice...

Cell-to-Muscle homogenization. Application to a constitutive law for the myocardium

Denis Caillerie, Ayman Mourad, Annie Raoult (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

We derive a constitutive law for the myocardium from the description of both the geometrical arrangement of cardiomyocytes and their individual mechanical behaviour. We model a set of cardiomyocytes by a quasiperiodic discrete lattice of elastic bars interacting by means of moments. We work in a large displacement framework and we use a discrete homogenization technique. The macroscopic constitutive law is obtained through the resolution of a nonlinear self-equilibrum system of the discrete lattice...

Comparison of Perron and Floquet Eigenvalues in Age Structured Cell Division Cycle Models

J. Clairambault, S. Gaubert, Th. Lepoutre (2009)

Mathematical Modelling of Natural Phenomena

We study the growth rate of a cell population that follows an age-structured PDE with time-periodic coefficients. Our motivation comes from the comparison between experimental tumor growth curves in mice endowed with intact or disrupted circadian clocks, known to exert their influence on the cell division cycle. We compare the growth rate of the model controlled by a time-periodic control on its coefficients with the growth rate of stationary models of the same nature, but with averaged coefficients....

Compartmental Models of Migratory Dynamics

J. Knisley, T. Schmickl, I. Karsai (2011)

Mathematical Modelling of Natural Phenomena

Compartmentalization is a general principle in biological systems which is observable on all size scales, ranging from organelles inside of cells, cells in histology, and up to the level of groups, herds, swarms, meta-populations, and populations. Compartmental models are often used to model such phenomena, but such models can be both highly nonlinear and difficult to work with.Fortunately, there are many significant biological systems that are amenable to linear compartmental models which are often...

Could changes in national tuberculosis vaccination policies be ill-informed ?

D.J. Gerberry, F.A. Milner (2012)

Mathematical Modelling of Natural Phenomena

National policies regarding the BCG vaccine for tuberculosis vary greatly throughout the international community and several countries are currently considering discontinuing universal vaccination. Detractors of BCG point to its uncertain effectiveness and its interference with the detection and treatment of latent tuberculosis infection (LTBI). In order to quantify the trade-off between vaccination and treatment of LTBI, a mathematical model was designed and calibrated to data from Brazil, Ghana,...

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