The common ancestor process for a Wright-Fisher diffusion.
The tree of life and other affine buildings.
The Uniform Minimum-Ones 2SAT Problem and its Application to Haplotype Classification
Analyzing genomic data for finding those gene variations which are responsible for hereditary diseases is one of the great challenges in modern bioinformatics. In many living beings (including the human), every gene is present in two copies, inherited from the two parents, the so-called haplotypes. In this paper, we propose a simple combinatorial model for classifying the set of haplotypes in a population according to their responsibility for a certain genetic disease. This model is based...
Two algorithms based on Markov chains and their application to recognition of protein coding genes in prokaryotic genomes
Methods based on the theory of Markov chains are most commonly used in the recognition of protein coding sequences. However, they require big learning sets to fill up all elements in transition probability matrices describing dependence between nucleotides in the analyzed sequences. Moreover, gene prediction is strongly influenced by the nucleotide bias measured by e.g. G+C content. In this paper we compare two methods: (i) the classical GeneMark algorithm, which uses a three-periodic non-homogeneous...