We prove some results in the context of isoperimetric inequalities with quantitative terms. In the $2$-dimensional case, our main contribution is a method for determining the optimal coefficients $c_1,...,c_m$ in the inequality $\delta P\left(E\right)\ge {\sum }_{k=1}^m{c}_k\alpha {\left(E\right)}^k+o\left(\alpha {\left(E\right)}^m\right)$, valid for each Borel set $E$ with positive and finite area, with $\delta P\left(E\right)$ and $\alpha \left(E\right)$ being, respectively, the $\mathrm{𝑖𝑠𝑜𝑝𝑒𝑟𝑖𝑚𝑒𝑡𝑟𝑖𝑐𝑑𝑒𝑓𝑖𝑐𝑖𝑡}$ and the $\mathrm{𝐹𝑟𝑎𝑒𝑛𝑘𝑒𝑙𝑎𝑠𝑦𝑚𝑚𝑒𝑡𝑟𝑦}$ of $E$. In $n$ dimensions, besides proving existence and regularity properties of minimizers for a wide class of $\mathrm{𝑞𝑢𝑎𝑛𝑡𝑖𝑡𝑎𝑡𝑖𝑣𝑒𝑖𝑠𝑜𝑝𝑒𝑟𝑖𝑚𝑒𝑡𝑟𝑖𝑐𝑞𝑢𝑜𝑡𝑖𝑒𝑛𝑡𝑠}$ including the lower semicontinuous extension of $\frac{\delta P\left(E\right)}{\alpha {\left(E\right)}^2}$, we describe the...