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The emergence of multidrug resistance among gram-negative bacilli is complex. Numerous
factors need to be considered, including the biological fitness cost of resistance, fitnesscompensatory
mutations and frequency and type of antibiotic exposure. A mathematical model
evaluating these complex relationships was developed in an individual colonized with strains of
pan-susceptible, single-, two- and multidrug-resistant (MDR) gram-negative bacilli (GN). The effect
of bacterial fitness, compensatory...
The aim of this study was to describe and analyze the regulation and spatio-temporal
dynamics of melanocyte migration in vitro and its coupling to cell
division and interaction with the matrix. The melanocyte lineage is particularly
interesting because it is involved in both embryonic development and
oncogenesis/metastasis (melanoma). Biological experiments were performed on two melanocyte
cell lines established from wild-type and β-catenin-transgenic...
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