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4D Embryogenesis image analysis using PDE methods of image processing

Paul Bourgine, Róbert Čunderlík, Olga Drblíková-Stašová, Karol Mikula, Mariana Remešíková, Nadine Peyriéras, Barbara Rizzi, Alessandro Sarti (2010)


In this paper, we introduce a set of methods for processing and analyzing long time series of 3D images representing embryo evolution. The images are obtained by in vivo scanning using a confocal microscope where one of the channels represents the cell nuclei and the other one the cell membranes. Our image processing chain consists of three steps: image filtering, object counting (center detection) and segmentation. The corresponding methods are based on numerical solution of nonlinear PDEs, namely...

A biochemical multi-species quality model of a drinking water distribution system for simulation and design

Krzysztof Arminski, Tomasz Zubowicz, Mietek A. Brdys (2013)

International Journal of Applied Mathematics and Computer Science

Drinking Water Distribution Systems (DWDSs) play a key role in sustainable development of modern society. They are classified as critical infrastructure systems. This imposes a large set of highly demanding requirements on the DWDS operation and requires dedicated algorithms for on-line monitoring and control to tackle related problems. Requirements on DWDS availability restrict the usability of the real plant in the design phase. Thus, a proper model is crucial. Within this paper a DWDS multi-species...

A comparison of coupled and uncoupled solvers for the cardiac Bidomain model

P. Colli Franzone, L. F. Pavarino, S. Scacchi (2013)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

The aim of this work is to compare a new uncoupled solver for the cardiac Bidomain model with a usual coupled solver. The Bidomain model describes the bioelectric activity of the cardiac tissue and consists of a system of a non-linear parabolic reaction-diffusion partial differential equation (PDE) and an elliptic linear PDE. This system models at macroscopic level the evolution of the transmembrane and extracellular electric potentials of the anisotropic cardiac tissue. The evolution equation is...

A Computational Framework to Assess the Efficacy of Cytotoxic Molecules and Vascular Disrupting Agents against Solid Tumours

M. Pons-Salort, B. van der Sanden, A. Juhem, A. Popov, A. Stéphanou (2012)

Mathematical Modelling of Natural Phenomena

A computational framework for testing the effects of cytotoxic molecules, specific to a given phase of the cell cycle, and vascular disrupting agents (VDAs) is presented. The model is based on a cellular automaton to describe tumour cell states transitions from proliferation to death. It is coupled with a model describing the tumour vasculature and its adaptation to the blood rheological constraints when alterations are induced by VDAs treatment....

A Cost-Effectiveness-Assessing Model of Vaccination for Varicella and Zoster

M. Comba, S. Martorano-Raimundo, E. Venturino (2012)

Mathematical Modelling of Natural Phenomena

A decision analytical model is presented and analysed to assess the effectiveness and cost-effectiveness of routine vaccination against varicella and herpes-zoster, or shingles. These diseases have as common aetiological agent the varicella-zoster virus (VZV). Zoster can more likely occur in aged people with declining cell-mediated immunity. The general concern is that universal varicella vaccination might lead to more cases of zoster: with more...

A dominant height growth model for eucalyptus plantations in Portugal

Ayana Mateus, Margarida Tomé (2009)

Discussiones Mathematicae Probability and Statistics

Eucalyptus globulus Labill is one of the most important economic forest species in Portugal, occupying an area of 875.10³ ha in a total forest area of 3346.10³ ha (Tomé et al., 2007). The main goal of this study is to develop a dominant height growth model for Eucalyptus, applicable throughout the country, representing an improve of the curves that are part of the whole stand model existing in Portugal, the GLOBULUS model (Tomé et al., 2001). The dominant height growth model will be built on a biological...

A Finite Element Model Based on Discontinuous Galerkin Methods on Moving Grids for Vertebrate Limb Pattern Formation

J. Zhu, Y.-T. Zhang, S. A. Newman, M. S. Alber (2009)

Mathematical Modelling of Natural Phenomena

Skeletal patterning in the vertebrate limb, i.e., the spatiotemporal regulation of cartilage differentiation (chondrogenesis) during embryogenesis and regeneration, is one of the best studied examples of a multicellular developmental process. Recently [Alber et al., The morphostatic limit for a model of skeletal pattern formation in the vertebrate limb, Bulletin of Mathematical Biology, 2008, v70, pp. 460-483], a simplified two-equation reaction-diffusion system was developed to describe the interaction...

A Galerkin strategy with Proper Orthogonal Decomposition for parameter-dependent problems – Analysis, assessments and applications to parameter estimation

D. Chapelle, A. Gariah, P. Moireau, J. Sainte-Marie (2013)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

We address the issue of parameter variations in POD approximations of time-dependent problems, without any specific restriction on the form of parameter dependence. Considering a parabolic model problem, we propose a POD construction strategy allowing us to obtain some a priori error estimates controlled by the POD remainder – in the construction procedure – and some parameter-wise interpolation errors for the model solutions. We provide a thorough numerical assessment of this strategy with the...

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