While drawing a link between the papers contained in this issue and those present in a previous one (Vol. 2, Issue 3), this introductory article aims at putting in evidence some trends and challenges on cancer modelling, especially related to the development of multiphase and multiscale models.
Let ξ be a polynomial vector field on with coefficients of degree d and P be a polynomial of degree p. We are interested in bounding the multiplicity of a zero of a restriction of P to a non-singular trajectory of ξ, when P does not vanish identically on this trajectory. Bounds doubly exponential in terms of n are already known ([9,5,10]). In this paper, we prove that, when n=3, there is a bound of the form . In Control Theory, such a bound can be used to give an estimate of the degree of nonholonomy...
In this paper we develop and study numerically a model to describe some aspects of sound propagation in the human lung, considered as a deformable and viscoelastic porous medium (the parenchyma) with millions of alveoli filled with air. Transmission of sound through the lung above 1 kHz is known to be highly frequency-dependent. We pursue the key idea that the viscoelastic parenchyma structure is highly heterogeneous on the small scale ε and use two-scale homogenization techniques to derive effective...
This paper deals with the problem of designing Nash equilibrium points in noncooperative games in which agents anticipate values of Lagrange multipliers coordinating their payoff functions. The addressed model of agents' interactions, referred to as the price-anticipation game, is studied within the framework of coordination and mechanism design theory for hierarchical systems. Sufficient conditions are formulated for Nash implementation of a regular and isolated solution to a coordination problem....
The problem of designing realistic decentralized controller to solve a servomechanism problem in the framework of “large scale systems” is considered in this paper. As any large scale system is built by expanding construction of one subsystem being connected to the existing system. In particular, it is desired to find a local stabilizing controller in terms of a free parameter (belonging to the ring of proper stable transfer functions) so that desirable properties of the controlled system, such...
In this work, we propose a methodology for the expression of necessary and sufficient Lyapunov-like conditions for the existence of stabilizing feedback laws. The methodology is an extension of the well-known Control Lyapunov Function (CLF) method and can be applied to very general nonlinear time-varying systems with disturbance and control inputs, including both finite and infinite-dimensional systems. The generality of the proposed methodology is also reflected upon by the fact that partial...
An optimal control problem is studied for a Lotka-Volterra system of three differential equations. It models an ecosystem of three species which coexist. The species are supposed to be separated from each others. Mathematically, this is modeled with the aid of two control variables. Some necessary conditions of optimality are found in order to maximize the total number of individuals at the end of a given time interval.