The authors consider the boundary value problem with a two-parameter nonhomogeneous multi-point boundary condition $$\begin{array}{c}{u}^{\text{'}\text{'}}+g\left(t\right)f(t,u)=0,t\in (0,1),\\ u\left(0\right)=\alpha u\left(\xi \right)+\lambda ,u\left(1\right)=\beta u\left(\eta \right)+\mu .Criteriafortheexistenceofnontrivialsolutionsoftheproblemareestablished.Thenonlineartermf(t,x)maytakenegativevaluesandmaybeunboundedfrombelow.Conditionsaredeterminedbytherelationshipbetweenthebehavioroff(t,x)/xforxnear0and\pm \infty ,andthesmallestpositivecharacteristicvalueofanassociatedlinearintegraloperator.Theanalysismainlyreliesontopologicaldegreetheory.Thisworkcomplementssomerecentresultsintheliterature.Theresultsareillustratedwithexamples.\end{array}$$

In this paper, we are concerned with the existence of solutions of the following multi-point boundary value problem consisting of the higher-order differential equation $$x^{\left(n\right)}\left(t\right)=f(t,x\left(t\right),x^{\text{'}}\left(t\right),\cdots ,x^{(n-1)}\left(t\right))+e\left(t\right),0<t<1,(*)$$ and the following multi-point boundary value conditions $$\begin{array}{cc}\hfill 1*-1x^{\left(i\right)}\left(0\right)& =0fori=0,1,\cdots ,n-3,\hfill \\ \hfill x^{(n-1)}\left(0\right)& =\alpha x^{(n-1)}\left(\xi \right),x^{(n-2)}\left(1\right)=\sum _{i=1}^m{\beta }_i{x}^{(n-2)}\left({\eta }_i\right).**\hfill \end{array}$$ Sufficient conditions for the existence of at least one solution of the BVP $(*)$ and $(**)$ at resonance are established. The results obtained generalize and complement those in [13, 14]. This paper is directly motivated by Liu and Yu [J. Pure Appl. Math. 33 (4)(2002), 475–494...