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The Influence of Look-Ahead on the Error Rate of Transcription

Y. R. Yamada, C. S. Peskin (2010)

Mathematical Modelling of Natural Phenomena

In this paper we study the error rate of RNA synthesis in the look-ahead model for the random walk of RNA polymerase along DNA during transcription. The model’s central assumption is the existence of a window of activity in which ribonucleoside triphosphates (rNTPs) bind reversibly to the template DNA strand before being hydrolyzed and linked covalently to the nascent RNA chain. An unknown, but important, integer parameter of this model is the window...

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