Some results on the influence of extremes on the bootstrap
In most clinical studies, patients are observed for extended time periods to evaluate influences in treatment such as drug treatment, approaches to surgery, etc. The primary event in these studies is death, relapse, adverse drug reaction, or development of a new disease. The follow-up time may range from few weeks to many years. Although these studies are long term, the number of observed events is small. Longitudinal studies have increased the importance of statistical methods for time-to event...