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Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor

Nathalie Verdiere, Lilianne Denis-Vidal, Ghislaine Joly-Blanchard, Dominique Domurado (2005)

International Journal of Applied Mathematics and Computer Science

The aim of this paper is numerical estimation of pharmacokinetic parameters of the ligands of the macrophage mannose receptor, without knowing it a priori the values of these parameters. However, it first requires a model identifiability analysis, which is done by applying an algorithm implemented in a symbolic computation language. It is shown that this step can lead to a direct numerical estimation algorithm. In this way, a first estimate is computed from noisy simulated observations without it...

Incorporating patients' characteristics in cost-effectiveness studies with clinical trial data: a flexible Bayesian approach.

Francisco José Vázquez Polo, Miguel Angel Negrín Hernández (2004)

SORT

Most published research on the comparison between medical treatment options merely compares the results (effectiveness and cost) obtained for each treatment group. The present work proposes the incorporation of other patient characteristics into the analysis. Most of the studies carried out in this context assume normality of both costs and effectiveness. In practice, however, the data are not always distributed according to this assumption. Alternative models have to be developed.In this paper,...

Indirect inference for survival data.

Bruce W. Turnbull, Wenxin Jiang (2003)

SORT

In this paper we describe the so-called indirect method of inference, originally developed from the econometric literature, and apply it to survival analyses of two data sets with repeated events. This method is often more convenient computationally than maximum likelihood estimation when handling such model complexities as random effects and measurement error, for example; and it can also serve as a basis for robust inference with less stringent assumptions on the data generating mechanism. The...

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