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Regulatory network of drug-induced enzyme production: parameter estimation based on the periodic dosing response measurement

Papáček, Štěpán, Lynnyk, Volodymyr, Rehák, Branislav (2021)

Programs and Algorithms of Numerical Mathematics

The common goal of systems pharmacology, i.e. systems biology applied to the field of pharmacology, is to rely less on trial and error in designing an input-output systems, e.g. therapeutic schedules. In this paper we present, on the paradigmatic example of a regulatory network of drug-induced enzyme production, the further development of the study published by Duintjer Tebbens et al. (2019) in the Applications of Mathematics. Here, the key feature is that the nonlinear model in form of an ODE system...

Remarks on polynomial methods for solving systems of linear algebraic equations

Krzysztof Moszyński (1992)

Applications of Mathematics

For a large system of linear algebraic equations A x = b , the approximate solution x k is computed as the k -th order Fourier development of the function 1 / z , related to orthogonal polynomials in L 2 ( Ω ) space. The domain Ω in the complex plane is assumed to be known. This domain contains the spectrum σ ( A ) of the matrix A . Two algorithms for x k are discussed. Two possibilities of preconditioning by an application of the so called Richardson iteration process with a constant relaxation coefficient are proposed. The case...

Replicant compression coding in Besov spaces

Gérard Kerkyacharian, Dominique Picard (2010)

ESAIM: Probability and Statistics

We present here a new proof of the theorem of Birman and Solomyak on the metric entropy of the unit ball of a Besov space B π , q s on a regular domain of d . The result is: if s - d(1/π - 1/p)+> 0, then the Kolmogorov metric entropy satisfies H(ε) ~ ε-d/s. This proof takes advantage of the representation of such spaces on wavelet type bases and extends the result to more general spaces. The lower bound is a consequence of very simple probabilistic exponential inequalities. To prove the upper bound,...

Replicant compression coding in Besov spaces

Gérard Kerkyacharian, Dominique Picard (2003)

ESAIM: Probability and Statistics

We present here a new proof of the theorem of Birman and Solomyak on the metric entropy of the unit ball of a Besov space B π , q s on a regular domain of d . The result is: if s - d ( 1 / π - 1 / p ) + > 0 , then the Kolmogorov metric entropy satisfies H ( ϵ ) ϵ - d / s . This...

Residual norm behavior for Hybrid LSQR regularization

Havelková, Eva, Hnětynková, Iveta (2023)

Programs and Algorithms of Numerical Mathematics

Hybrid LSQR represents a powerful method for regularization of large-scale discrete inverse problems, where ill-conditioning of the model matrix and ill-posedness of the problem make the solutions seriously sensitive to the unknown noise in the data. Hybrid LSQR combines the iterative Golub-Kahan bidiagonalization with the Tikhonov regularization of the projected problem. While the behavior of the residual norm for the pure LSQR is well understood and can be used to construct a stopping criterion,...

Resilient asynchronous primal Schur method

Guillaume Gbikpi-Benissan, Frédéric Magoulès (2022)

Applications of Mathematics

This paper introduces the application of asynchronous iterations theory within the framework of the primal Schur domain decomposition method. A suitable relaxation scheme is designed, whose asynchronous convergence is established under classical spectral radius conditions. For the usual case where local Schur complement matrices are not constructed, suitable splittings based only on explicitly generated matrices are provided. Numerical experiments are conducted on a supercomputer for both Poisson's...

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