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Hematologic Disorders and Bone Marrow–Peripheral Blood Dynamics

E. Afenya, S. Mundle (2010)

Mathematical Modelling of Natural Phenomena

Hematologic disorders such as the myelodysplastic syndromes (MDS) are discussed. The lingering controversies related to various diseases are highlighted. A simple biomathematical model of bone marrow - peripheral blood dynamics in the normal state is proposed and used to investigate cell behavior in normal hematopoiesis from a mathematical viewpoint. Analysis of the steady state and properties of the model are used to make postulations about the...

Human Immunodeficiency Virus Infection : from Biological Observations to Mechanistic Mathematical Modelling

G. Bocharov, V. Chereshnev, I. Gainova, S. Bazhan, B. Bachmetyev, J. Argilaguet, J. Martinez, A. Meyerhans (2012)

Mathematical Modelling of Natural Phenomena

HIV infection is multi-faceted and a multi-step process. The virus-induced pathogenic mechanisms are manifold and mediated through a range of positive and negative feedback regulations of immune and physiological processes engaged in virus-host interactions. The fundamental questions towards understanding the pathogenesis of HIV infection are now shifting to ‘dynamic’ categories: (i) why is the HIV-immune response equilibrium finally disrupted? (ii)...

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