Cancer has recently overtaken heart disease as the world’s biggest killer. Cancer is initiated by gene mutations that result in local proliferation of abnormal cells and their migration to other parts of the human body, a process called metastasis. The metastasized cancer cells then interfere with the normal functions of the body, eventually leading to death. There are two hundred types of cancer, classified by their point of origin. Most of them...
In this work, we introduce a new software created to study hematopoiesis at the cell population level with the individually based approach. It can be used as an interface between theoretical works on population dynamics and experimental observations. We show that this software can be useful to study some features of normal hematopoiesis as well as some blood diseases such as myelogenous leukemia. It is also possible to simulate cell communication and the formation of cell colonies in the bone marrow. ...
We develop a method for counting number of cells and extraction of approximate cell centers in 2D and 3D images of early stages of the zebra-fish embryogenesis. The approximate cell centers give us the starting points for the subjective surface based cell segmentation. We move in the inner normal direction all level sets of nuclei and membranes images by a constant speed with slight regularization of this flow by the (mean) curvature. Such multi- scale evolutionary process is represented by a geometrical...