Page 1

Displaying 1 – 5 of 5

Showing per page

Data mining methods for gene selection on the basis of gene expression arrays

Michał Muszyński, Stanisław Osowski (2014)

International Journal of Applied Mathematics and Computer Science

The paper presents data mining methods applied to gene selection for recognition of a particular type of prostate cancer on the basis of gene expression arrays. Several chosen methods of gene selection, including the Fisher method, correlation of gene with a class, application of the support vector machine and statistical hypotheses, are compared on the basis of clustering measures. The results of applying these individual selection methods are combined together to identify the most often selected...

Deterministic and stochastic simulations of simple genetic circuits

Ofer Biham, Nathalie Q. Balaban, Adiel Loinger, Azi Lipshtat, Hagai B. Perets (2008)

Banach Center Publications

We analyze three simple genetic circuits which involve transcriptional regulation and feedback: the autorepressor, the switch and the repressilator, that consist of one, two and three genes, respectively. Such systems are commonly simulated using rate equations, that account for the concentrations of the mRNAs and proteins produced by these genes. Rate equations are suitable when the concentrations of the relevant molecules in a cell are large and fluctuations are negligible. However, when some...

Diffusion limit for the phenomenon of random genetic drift

Anna Marciniak (2000)

Applicationes Mathematicae

The paper deals with mathematical modelling of population genetics processes. The formulated model describes the random genetic drift. The fluctuations of gene frequency in consecutive generations are described in terms of a random walk. The position of a moving particle is interpreted as the state of the population expressed as the frequency of appearance of a specific gene. This leads to a continuous model on the microscopic level in the form of two first order differential equations (known as...

Drift, draft and structure: some mathematical models of evolution

Alison M. Etheridge (2008)

Banach Center Publications

Understanding the evolution of individuals which live in a structured and fluctuating environment is of central importance in mathematical population genetics. Here we outline some of the mathematical challenges arising from modelling structured populations, primarily focussing on the interplay between forwards in time models for the evolution of the population and backwards in time models for the genealogical trees relating individuals in a sample from that population. In addition to classical...

Currently displaying 1 – 5 of 5

Page 1