Factor-union representation of phenotype systems.
Free Boundary Problems Associated with Multiscale Tumor Models
The present paper introduces a tumor model with two time scales, the time t during which the tumor grows and the cycle time of individual cells. The model also includes the effects of gene mutations on the population density of the tumor cells. The model is formulated as a free boundary problem for a coupled system of elliptic, parabolic and hyperbolic equations within the tumor region, with nonlinear and nonlocal terms. Existence and uniqueness theorems are proved, and properties of the free boundary...
From convergence of operator semigroups to gene expression, and back again
The subject of the paper is reciprocal influence of pure mathematics and applied sciences. We illustrate the idea by giving a review of mathematical results obtained recently, related to the model of stochastic gene expression due to Lipniacki et al. [38]. In this model, featuring mRNA and protein levels, and gene activity, the stochastic part of processes involved in gene expression is distinguished from the part that seems to be mostly deterministic, and the dynamics is expressed by means of a...