Perturbations of Positive Semigroups and Applications to Population Genetics.
Population genetics models for the statistics of DNA samples under different demographic scenarios - Maximum likelihood versus approximate methods
The paper reviews the basic mathematical methodology of modeling neutral genetic evolution, including the statistics of the Fisher-Wright process, models of mutation and the coalescence method under various demographic scenarios. The basic approach is the use of maximum likelihood techniques. However, due to computational problems, intuitive or approximate methods are also of great importance.
Progressive diseases: Interpretation of genetic data.
Properties of a singular value decomposition based dynamical model of gene expression data
Recently, data on multiple gene expression at sequential time points were analyzed using the Singular Value Decomposition (SVD) as a means to capture dominant trends, called characteristic modes, followed by the fitting of a linear discrete-time dynamical system in which the expression values at a given time point are linear combinations of the values at a previous time point. We attempt to address several aspects of the method. To obtain the model, we formulate a nonlinear optimization problem...