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A Mathematical Model of Cancer Stem Cell Lineage Population Dynamics with Mutation Accumulation and Telomere Length Hierarchies

G. Kapitanov (2012)

Mathematical Modelling of Natural Phenomena

There is evidence that cancer develops when cells acquire a sequence of mutations that alter normal cell characteristics. This sequence determines a hierarchy among the cells, based on how many more mutations they need to accumulate in order to become cancerous. When cells divide, they exhibit telomere loss and differentiate, which defines another cell hierarchy, on top of which is the stem cell. We propose a mutation-generation model, which combines...

A mathematical model of inflammation during ischemic stroke

Cristiana Di Russo, Jean-Baptiste Lagaert, Guillemette Chapuisat, Marie-Aimée Dronne (2010)

ESAIM: Proceedings

In this article we propose a model to describe the inflammatory process which occurs during ischemic stroke. First, an introduction to some basic concepts about the biological phenomenon is given. Then, a detailed derivation of the model and the numerical scheme used are presented. Finally, the studies of the model robustness and sensitivity are showed and some numerical results on the time and space evolution of the process are presented and discussed....

A matrix constructive method for the analytic-numerical solution of coupled partial differential systems

Lucas Jódar, Enrique A. Navarro, M. V. Ferrer (1995)

Applications of Mathematics

In this paper we construct analytic-numerical solutions for initial-boundary value systems related to the equation u t - A u x x - B u = 0 , where B is an arbitrary square complex matrix and A ia s matrix such that the real part of the eigenvalues of the matrix 1 2 ( A + A H ) is positive. Given an admissible error ε and a finite domain G , and analytic-numerical solution whose error is uniformly upper bounded by ε in G , is constructed.

A mechanochemical model of angiogenesis and vasculogenesis

Daphne Manoussaki (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

Vasculogenesis and angiogenesis are two different mechanisms for blood vessel formation. Angiogenesis occurs when new vessels sprout from pre-existing vasculature in response to external chemical stimuli. Vasculogenesis occurs via the reorganization of randomly distributed cells into a blood vessel network. Experimental models of vasculogenesis have suggested that the cells exert traction forces onto the extracellular matrix and that these forces may play an important role in the network forming...

A mechanochemical model of angiogenesis and vasculogenesis

Daphne Manoussaki (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

Vasculogenesis and angiogenesis are two different mechanisms for blood vessel formation. Angiogenesis occurs when new vessels sprout from pre-existing vasculature in response to external chemical stimuli. Vasculogenesis occurs via the reorganization of randomly distributed cells into a blood vessel network. Experimental models of vasculogenesis have suggested that the cells exert traction forces onto the extracellular matrix and that these forces may play an important role in the network forming...

A method for determining constants in the linear combination of exponentials

Jiří Cerha (1996)

Mathematica Bohemica

Shifting a numerically given function b 1 exp a 1 t + ⋯ + b n exp a n t we obtain a fundamental matrix of the linear differential system y ˙ = A y with a constant matrix A . Using the fundamental matrix we calculate A , calculating the eigenvalues of A we obtain a 1 , ⋯ , a n and using the least square method we determine b 1 , ⋯ , b n .

A method for knowledge integration

Martin Janžura, Pavel Boček (1998)

Kybernetika

With the aid of Markov Chain Monte Carlo methods we can sample even from complex multi-dimensional distributions which cannot be exactly calculated. Thus, an application to the problem of knowledge integration (e. g. in expert systems) is straightforward.

Currently displaying 401 – 420 of 9149