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A mathematical model describing the thyroid-pituitary axis with time delays in hormone transportation

Banibrata Mukhopadhyay, Rakhi Bhattacharyya (2006)

Applications of Mathematics

In the present paper, a mathematical model, originally proposed by Danziger and Elmergreen and describing the thyroid-pituitary homeostatic mechanism, is modified and analyzed for its physiological and clinical significance. The influence of different system parameters on the stability behavior of the system is discussed. The transportation delays of different hormones in the bloodstream, both in the discrete and distributed forms, are considered. Delayed models are analyzed regarding the stability...

Analysis of immunotherapy models in the context of cancer dynamics

Zuzanna Szymańska (2003)

International Journal of Applied Mathematics and Computer Science

A basic mathematical model of the immune response when cancer cells are recognized is proposed. The model consists of six ordinary differential equations. It is extended by taking into account two types of immunotherapy: active immunotherapy and adoptive immunotherapy. An analysis of the corresponding models is made to answer the question which of the presented methods of immunotherapy is better. The analysis is completed by numerical simulations which show that the method of adoptive immunotherapy...

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