Given a compact manifold $N^n\subset {ℝ}^{\nu }$ and real numbers $s\ge 1$ and $1\le p\<\infty$, we prove that the class $C^{\infty }({\overline{Q}}^m;N^n)$ of smooth maps on the cube with values into $N^n$ is strongly dense in the fractional Sobolev space $W^{s,p}(Q^m;N^n)$ when $N^n$ is $\lfloor sp\rfloor$ simply connected. For $sp$ integer, we prove weak sequential density of $C^{\infty }({\overline{Q}}^m;N^n)$ when $N^n$ is $sp-1$ simply connected. The proofs are based on the existence of a retraction of ${ℝ}^{\nu }$ onto $N^n$ except for a small subset of $N^n$ and on a pointwise estimate of fractional derivatives of composition of maps in $W^{s,p}\cap W^{1,sp}$.