The search session has expired. Please query the service again.
A computational framework for testing the effects of cytotoxic molecules, specific to a
given phase of the cell cycle, and vascular disrupting agents (VDAs) is presented. The
model is based on a cellular automaton to describe tumour cell states transitions from
proliferation to death. It is coupled with a model describing the tumour vasculature and
its adaptation to the blood rheological constraints when alterations are induced by VDAs
treatment....
Eucalyptus globulus Labill is one of the most important economic forest species in Portugal, occupying an area of 875.10³ ha in a total forest area of 3346.10³ ha (Tomé et al., 2007). The main goal of this study is to develop a dominant height growth model for Eucalyptus, applicable throughout the country, representing an improve of the curves that are part of the whole stand model existing in Portugal, the GLOBULUS model (Tomé et al., 2001). The dominant height growth model will be built on a biological...
In this paper we deal with a semilinear hyperbolic chemotaxis model in one space dimension evolving on a network, with suitable transmission conditions at nodes. This framework is motivated by tissue-engineering scaffolds used for improving wound healing. We introduce a numerical scheme, which guarantees global mass densities conservation. Moreover our scheme is able to yield a correct approximation of the effects of the source term at equilibrium. Several numerical tests are presented to show the...
We propose a quasi-Newton algorithm for solving fluid-structure interaction problems. The basic idea of the method is to build an approximate tangent operator which is cost effective and which takes into account the so-called added mass effect. Various test cases show that the method allows a significant reduction of the computational effort compared to relaxed fixed point algorithms. We present 2D and 3D fluid-structure simulations performed either with a simple 1D structure model or with shells...
We propose a quasi-Newton algorithm for solving
fluid-structure interaction problems. The basic idea of the method is
to build an approximate tangent operator which is cost effective and
which takes into account the so-called added mass effect.
Various test cases show that the method allows a significant reduction
of the computational effort compared to relaxed fixed point
algorithms. We present 2D and 3D fluid-structure simulations performed
either with a simple 1D structure model or with...
A hyperelastic constitutive law, for use in anatomically accurate finite element models of living structures, is suggested for the passive and the active mechanical properties of incompressible biological tissues. This law considers the passive and active states as a same hyperelastic continuum medium, and uses an activation function in order to describe the whole contraction phase. The variational and the FE formulations are also presented, and the FE code has been validated and applied to describe...
A hyperelastic constitutive law, for use in anatomically accurate finite element models of
living structures, is suggested for the passive and the active mechanical properties of incompressible
biological tissues. This law considers the passive and active states as a same hyperelastic continuum
medium, and uses an activation function in order to describe the whole contraction phase.
The variational and the FE formulations are also presented, and the FE code has been validated
and applied to describe...
Zernike polynomials have been widely used in the description and shape retrieval of 3D objects. These orthonormal polynomials allow for efficient description and reconstruction of objects that can be scaled to fit within the unit ball. However, maps defined within box-shaped regions ¶ for example, rectangular prisms or cubes ¶ are not well suited to representation by Zernike polynomials, because these functions are not orthogonal over such regions. In particular, the representations require many...
Many cancer-associated genes and pathways remain to be identified in order to clarify the
molecular mechanisms underlying cancer progression. In this area, genome-wide
loss-of-function screens appear to be powerful biological tools, allowing the accumulation
of large amounts of data. However, this approach currently lacks analytical tools to
exploit the data with maximum efficiency, for which systems biology methods analyzing
complex cellular networks...
Tuberculosis (TB) remains a major global health problem. A possible risk factor for TB is
diabetes (DM), which is predicted to increase dramatically over the next two decades,
particularly in low and middle income countries, where TB is widespread. This study aimed
to assess the strength of the association between TB and DM. We present a deterministic
model for TB in a community in order to determine the impact of DM in the spread of the
disease....
Currently displaying 1 –
12 of
12