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The Effect of Bacteria on Epidermal Wound Healing

E. Agyingi, S. Maggelakis, D. Ross (2010)

Mathematical Modelling of Natural Phenomena

Epidermal wound healing is a complex process that repairs injured tissue. The complexity of this process increases when bacteria are present in a wound; the bacteria interaction determines whether infection sets in. Because of underlying physiological problems infected wounds do not follow the normal healing pattern. In this paper we present a mathematical model of the healing of both infected and uninfected wounds. At the core of our model is an...

The onset of necrosis in a 3D cellular automaton model of EMT6 multi-cellular spheroids

Simon D. Angus, Monika J. Piotrowska (2010)

Applicationes Mathematicae

A 3-dimensional (3D) extension to a previously reported scaled 2-dimensional Cellular Automaton (CA) model of avascular multi-cellular spheroid growth is presented and analysed for the EMT6/Ro cell line. The model outputs are found to compare favourably with reported experimentally obtained data for in vitro spheroids of the same cell line. Necrosis (unprogrammed central cell death) is observed to be delayed when compared with the experimental data. Furthermore, it is found that necrosis arises...

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