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Mechanisms of Cell Motion in Confined Geometries

R. J. Hawkins, R. Voituriez (2010)

Mathematical Modelling of Natural Phenomena

We present a simple mechanism of cell motility in a confined geometry, inspired by recent motility assays in microfabricated channels. This mechanism relies mainly on the coupling of actin polymerisation at the cell membrane to geometric confinement. We first show analytically using a minimal model of polymerising viscoelastic gel confined in a narrow channel that spontaneous motion occurs due to polymerisation alone. Interestingly, this mechanism...

Molecular motors and stochastic networks

Reinhard Lipowsky, Steffen Liepelt (2008)

Banach Center Publications

Molecular motors are nano- or colloidal machines that keep the living cell in a highly ordered, stationary state far from equilibrium. This self-organized order is sustained by the energy transduction of the motors, which couple exergonic or 'downhill' processes to endergonic or 'uphill' processes. A particularly interesting case is provided by the chemomechanical coupling of cytoskeletal motors which use the chemical energy released during ATP hydrolysis in order to generate mechanical forces and...

Particle Dynamics Methods of Blood Flow Simulations

A. Tosenberger, V. Salnikov, N. Bessonov, E. Babushkina, V. Volpert (2011)

Mathematical Modelling of Natural Phenomena

Various particle methods are widely used to model dynamics of complex media. In this work molecular dynamics and dissipative particles dynamics are applied to model blood flows composed of plasma and erythrocytes. The properties of the homogeneous particle fluid are studied. Capillary flows with erythrocytes are investigated.

Progress in developing Poisson-Boltzmann equation solvers

Chuan Li, Lin Li, Marharyta Petukh, Emil Alexov (2013)

Molecular Based Mathematical Biology

This review outlines the recent progress made in developing more accurate and efficient solutions to model electrostatics in systems comprised of bio-macromolecules and nanoobjects, the last one referring to objects that do not have biological function themselves but nowadays are frequently used in biophysical and medical approaches in conjunction with bio-macromolecules. The problem of modeling macromolecular electrostatics is reviewed from two different angles: as a mathematical task provided...

Simulation of electrophysiological waves with an unstructured finite element method

Yves Bourgault, Marc Ethier, Victor G. LeBlanc (2003)

ESAIM: Mathematical Modelling and Numerical Analysis - Modélisation Mathématique et Analyse Numérique

Bidomain models are commonly used for studying and simulating electrophysiological waves in the cardiac tissue. Most of the time, the associated PDEs are solved using explicit finite difference methods on structured grids. We propose an implicit finite element method using unstructured grids for an anisotropic bidomain model. The impact and numerical requirements of unstructured grid methods is investigated using a test case with re-entrant waves.

Simulation of Electrophysiological Waves with an Unstructured Finite Element Method

Yves Bourgault, Marc Ethier, Victor G. LeBlanc (2010)

ESAIM: Mathematical Modelling and Numerical Analysis

Bidomain models are commonly used for studying and simulating electrophysiological waves in the cardiac tissue. Most of the time, the associated PDEs are solved using explicit finite difference methods on structured grids. We propose an implicit finite element method using unstructured grids for an anisotropic bidomain model. The impact and numerical requirements of unstructured grid methods is investigated using a test case with re-entrant waves.

Singular Perturbations For Heart Image Segmentation Tracking

J. Pousin (2009)

Mathematical Modelling of Natural Phenomena

In this note we give a result of convergence when time goes to infinity for a quasi static linear elastic model, the elastic tensor of which vanishes at infinity. This method is applied to segmentation of medical images, and improves the 'elastic deformable template' model introduced previously.

Steady state in a biological system: global asymptotic stability

Maria Adelaide Sneider (1988)

Atti della Accademia Nazionale dei Lincei. Classe di Scienze Fisiche, Matematiche e Naturali. Rendiconti Lincei. Matematica e Applicazioni

A suitable Liapunov function is constructed for proving that the unique critical point of a non-linear system of ordinary differential equations, considered in a well determined polyhedron K , is globally asymptotically stable in K . The analytic problem arises from an investigation concerning a steady state in a particular macromolecular system: the visual system represented by the pigment rhodopsin in the presence of light.

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